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Instructor: Brian Kuhlman; 919-428-334, bkuhlman@email.unc.edu

Meeting Dates, Times and Locations: late August to late September; MWF 11:00 AM; 3007 GMB.  Registration limited to 12 except with permission of Course Director. (Recitations will meet on Tuesdays and Thursdays, Time and location will be determined)

Binding and Linkage

  • Single Site Binding
  • Determinants of Binding Affinity and Specificity
  • Macroscopic representation of multiple-site binding / linkage
  • Ligand binding equilibria from a microscopic perspective / allostery (taught by Drew Lee)

Thermodynamics / Statistical Mechanics

  • Entropy
  • Linking Energy and Entropy / The Boltzmann Distribution
  • Free Energy
  • Chemical Potential and the Drive to Equilibrium