BIOC 650 Principles of Molecular Thermodynamics; Binding and Linkage

Instructor: Brian Kuhlman; 919-428-334, bkuhlman@email.unc.edu

Meeting Dates, Times and Locations: late August to late September; MWF 11:00 AM; 3007 GMB.  Registration limited to 12 except with permission of Course Director. (Recitations TBD)

Binding and Linkage

• Single Site Binding
• Determinants of Binding Affinity and Specificity
• Macroscopic representation of multiple-site binding / linkage
• Ligand binding equilibria from a microscopic perspective / allostery (taught by Drew Lee)

Thermodynamics / Statistical Mechanics

• Entropy
• Linking Energy and Entropy / The Boltzmann Distribution
• Free Energy
• Chemical Potential and the Drive to Equilibrium